"The gentle shampoo, it will not wash out spot on or topical flea and tick protection (use with Frontline, Advantage, K9 Advantix, Biospot, ProTicAll, and Revolution.) Bioguard's gentle water based formula lathers up quickly. Rinses out easily, yet will not wash out the protection of your pet's flea and tick control. Non irritating PH balanced formula cleans and conditions the coat and leaves a fresh clean scent. Safe for dogs, cats, kittens, and puppies of all ages."